atients with cancer admitted to critical care units are at increased risk of being affected with acute kidney injury (AKI) and mortality. Sustained low-efficiency dialysis (SLED) combines the cardiovascular stability of continuous therapy with the operational facility of conventional hemodialysis (HD). Citrate has become an alternative to heparin in anticoagulation because it favors the maintenance of filter patency and reduces bleeding. We analyzed the efficacy and safety of citrate versus heparin use in extended HD for patients with cancer and AKI. Methods: This retrospective cohort study evaluated patients with cancer and dialytic AKI who received SLED with anticoagulation using citrate versus heparin from January 2014 to June 2017.
Continue readingThe Influence Of Acute Kidney Disease
Background and Aims
Cisplatin (CDDP) is used as the first line of treatment for some tumors, but its use may be restricted due to its nephrotoxicity. Carboplatin (CARBO) and oxaliplatin (OXA) are less nephrotoxic alternatives to CDDP. This study has the objective to determine the incidence of acute kidney disease after chemotherapy with CDDP, CARBO, or OXA.
Prednisone monotherapy induced remission
The treatment of membranous lupus nephritis (MLN) is still controversial in the literature. We conducted a retrospective analysis of patients in two medical centers of São Paulo-Brazil in order to evaluate the clinical response in patients submitted to either a regimen with prednisone alone or to a double immunosuppressive regimen (prednisone plus cyclophosphamide or prednisone plus azathioprine).
Continue readingEvolution of chronic kidney disease
Renal cell carcinoma (CRC) is the 9th most common cancer in the world and its preferential treatment is partial nephrectomy (PN) in order to preserve more renal tissue and, consequently, its function. The amount of renal function preserved using this surgical method is still not well established and there may be the development of chronic kidney disease (CKD) even with PN. Aims: to evaluate the renal function of patients submitted to PN for localized renal tumors; to analyze the risk factors for progression of CKD in the postoperative period (PO) of PN.
Continue readingNon Oncologic Histological
Kidney cancer in adults accounts for 2% to 3% of all malignancies. Recent studies have demonstrated the prevalence of various chronic non-neoplastic morbidities in patients with renal cancer, such as hypertension and diabetes. It is not clear whether the finding of histological changes not directly related to renal cell carcinoma predicts an unfavorable evolution of renal function or even only indicates alterations secondary to these morbidities with no evident clinical significance. Aims: To evaluate the non-oncological histological findings found in the descriptions of the pieces resulting from the partial nephrectomy of patients with localized renal carcinoma; to correlate these changes with the associated chronic morbidities in these patients.
Continue readingRole of prognostic scores
Multiple myeloma (MM) has an average survival of seven years after chemotherapy and autologous bone marrow transplantation (BMT), being a common renal dysfunction associated with an early mortality. Currently, the most used scores to assess the prognosis of MM are Durie and Salmon (DS) and International Staging System (ISS) and there are few records of the work of these scores predicting renal damage after ABMT. Aims: to evaluate the scores of prognosis ISS and DS in renal function and mortality in patients with post BMT
Continue readingEvolution After Bone Medula Transplantation
One of the currently effective methods for the treatment of haematological malignancies is autologous (TAUMO) or allogeneic (TALMO) hematopoietic cell transplantation (TALMO), but it is associated with a combination of factors including sepsis, graft versus host disease, and nephrotoxic drugs may result in a study of acute renal injury (AKI). Aims: to evaluate the presence of AKI in patients with lymphomas or leukemia submitted to bone marrow transplantation (BMT).
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